Malassezia and the Skin by Teun Boekhout Peter Mayser Eveline Guého-Kellermann & Aristea Velegraki

Author:Teun Boekhout, Peter Mayser, Eveline Guého-Kellermann & Aristea Velegraki
Language: eng
Format: epub
Publisher: Springer Berlin Heidelberg, Berlin, Heidelberg

5.4.3.4 Psoriasis

The role that Malassezia plays in psoriasis has been a matter of debate and controversy. It is known that treatment of psoriatic scalp lesions with ketoconazole results in improvement of the lesions and concomitant decrease in Malassezia population densities [181, 182]. An attempt to understand their role was made by studying the response of T-cells from scalp psoriatic lesions and other sites, to see if Malassezia-specific T-cells were confined to the scalp [10]. Skin biopsies and blood were obtained from 13 patients with psoriasis and T-cell lines were derived from the skin by stimulation with ‘P. orbiculare’ (synonymous with M. globosa). Blood T-cell lines were derived by stimulation with either ‘P. ovale’ or ‘P. orbiculare.’ Proliferation responses did not differ significantly between the two organisms. With the scalp T-cell lines and T-cell lines from other sites, more of them responded to ‘P. orbiculare’ than ‘P. ovale.’ T-cell lines generated from patients with alopecia areata yielded similar results, suggesting that these T-cell lines are not related to the pathogenesis of psoriasis and may simply be a reflection of sensitisation due to colonisation by Malassezia on the scalp and other sites.

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